Vacancies

• Company: Exscientia
• Department: Associate Director reporting to Head of Toxicology
• Location: Hybrid (UK/Austria)
• Contract: Full-Time

Job Description

Exscientia is an AI-driven pharmatech company committed to discovering, designing and developing the best possible drugs in the fastest and most effective manner. Exscientia developed the first-ever functional precision oncology platform to successfully guide treatment selection and improve patient outcomes in a prospective interventional clinical study, as well as to progress AI-designed small molecules into the clinical setting.

Our pipeline demonstrates our ability to rapidly translate scientific concepts into precision-designed therapeutic candidates, with more than 15 projects underway. By designing better drugs, faster, we believe the best ideas of science can rapidly become the best medicines for patients.

The Role
The Discovery Toxicologist will join the innovative Preclinical Development group and will provide project teams with scientific expertise and leadership for the safety assessment of Exscientia programs from early discovery, through to candidate selection and beyond. You will contribute to the assessment and selection of novel drug targets and optimisation of novel candidate molecules using innovative molecular, cellular and in vivo technologies to maximise predictive safety science and investigative toxicology.

Please note this is a hybrid role and occasional travel is required to our labs/offices in Oxford, UK (approximately once a quarter), with flexibility to work from home the remaining time. We are a flexible working organisation and we’re willing to consider other options which would provide similar contact time with the team.

 You will have the opportunity to: 

• Represent Toxicology as the Subject Matter Expert on cross-functional project teams within the Discovery organisation. Opportunity to represent Toxicology in Development as the projects progress.
• Act as a key resource for early safety assessment during the drug discovery phase, providing scientific knowledge and expertise to cross-functional project teams.
• Use established toxicology screening strategies to predict, assess and mitigate target- and drug-related safety risks in support of the drug discovery portfolio.
• Refine and implement innovative experimental strategies and use the data to assess and /or provide mechanistic understanding of safety issues.
• Collaborate with CROs to ensure best practice for in vitro and/or in vivo safety assessment.
• Prepare verbal and written summaries for internal discussions. Work with the Discovery teams to develop optimal strategies to address specific safety issues within project teams. Present summary data to project teams, Exscientia senior leadership and external partners as needed.

Requirements
Essential skills:

• DVM, Pharm D, Ph.D in toxicology, Pathology, Physiology, Biochemistry or expertise in related biological scientific disciplines, with an emphasis on Oncology/Immunology is preferred. 10+ years’ experience in safety sciences in the Biotech/Pharma industry
• Experience in project team membership as a Discovery toxicology representative in a matrix environment
• Experience with in silico and in vitro safety assessment leading to an in-depth knowledge of discovery toxicology, and experience designing and critically evaluating results of exploratory toxicology studies
• An understanding of in vitro to in vivo translation of potential toxicities and implications for human safety
• Broad background in novel methods of identifying potential toxicities and developing risk mitigation plans
• Highly motivated scientist, who can work independently, with excellent oral/written communication skills

 Desirable skills:

• Board Certification in Toxicology (DABT/ERT)
• Experience running in vivo safety assessment studies
• Knowledge of secondary pharmacology assessment and mitigation of identified risks
• Keen interest in artificial intelligence and its application to drug discovery. Experience with the use of AI-tools to predict toxicology endpoints

Benefits:

• Join our inclusive, collaborative and intellectually stimulating organisation with strong company values.
• As a learning organisation, we provide access to learning and development opportunities and will place you at the forefront of your career growth at Exscientia.
• We employ brilliant people so we pay highly competitive salaries. Additionally, all our employees are eligible for a company-wide annual bonus and receive both a new joiner and annual share award.
• Enjoy our generous holiday allowance and flexible working approach to find a healthy work-life balance that works for you.
• Create amazing memories or progress your personal and professional development with our four-week paid sabbatical after four years of service.
• We’re leading the way in progressive leave, offering enhanced policies such as generous parental leave, surrogacy, menopause, and family emergency leave so you feel supported no matter the life event.
• Additionally, we support childcare costs for children aged 0-5 through our affordable childcare scheme.
• Take advantage of two generous salary exchange schemes to claim discounts on a brand new electric vehicle and cycling equipment worth up to £3,500.
• As a healthcare company, we understand the importance of health and wellbeing so we provide comprehensive private health insurance, dental and vision benefits for you and your family.
• We also provide plenty of access to mental health support including therapy and counselling sessions plus an employee assistance program for help with lifestyle issues such as bereavement, family problems or money management.
• To help safeguard the future for you and your loved ones, we also offer pension and life cover.
• Help yourself to free drinks and snacks in our fully stocked kitchens. Join your colleagues in one of our many breakout areas and get to know the people you are working with. Some of the best ideas start with a coffee break!
• Feel inspired in our high spec labs where you will use state-of-the-art equipment and instrumentation that enable you to do your best work.
• We’ll even support your home office environment with an allowance for furniture and equipment to make your space as comfortable and productive as possible.

To apply, please visit https://www.exscientia.ai/careers.

• Company: The Health and Safety Executive
• Salary: £40,788 - £46,783

Job Description

As a Senior Regulatory Toxicologist, you will assess the human health hazards and risks of a variety of chemicals.

 

Evaluating data from standard regulatory, non-standard and in vitro studies and mechanistic and literature information, you will contribute towards developing and shaping our regulatory schemes for the future.

 

You will also apply the relevant regulations, guidance and models in relation to complex and challenging situations to make important decisions on the hazard and risk assessment of chemicals.

 

Additionally, there will be opportunities for you to lead national and global activities to ensure we keep pace with new and emerging issues in regulatory toxicology.

 

Your role will also involve:

 

– Supporting junior members of the team

– Providing advice to specialist and policy colleagues and wider stakeholders

– Supporting the approval and authorisation of biocides and pesticides

 

Mandatory Skill Set Required

To be considered as a Senior Regulatory Toxicologist, you will need:

 

– Experience leading on relevant toxicology technical issues

– Experience in a regulatory or scientific area relevant to the role

– Experience undertaking human-health hazard and risk assessments of chemicals

– Experience leading teams and/or projects

– Experience of performing representational roles in relation to toxicology

– Comprehensive analytical skills

 

You will also need a degree at a minimum level of 2:2 or a level 7/8 qualification in a relevant science subject such as:

 

– Biochemistry

– Biological Sciences

– Biomedical Sciences

– Chemistry

– Pharmacology

– Pharmacy

– Toxicology

 

The closing date for this role is 13th May 2024

 

Other organisations may call this role Toxicologist, Toxicology Scientist, Regulatory Scientist, Senior Scientific Consultant, Senior Quality Control Scientist, Senior Research Scientist, or Senior Decisions Scientist.

 

Webrecruit and Health and Safety Executive are equal opportunities employers, value diversity and are strongly committed to providing equal employment opportunities for all employees and all applicants for employment. Equal opportunities are the only acceptable way to conduct business and we believe that the more inclusive our environments are, the better our work will be.

 

So, if you’re looking for a unique and rewarding role as a Senior Regulatory Toxicologist, please apply via the link shown. This vacancy is being advertised by Webrecruit. The services advertised by Webrecruit are those of an Employment Agency.

 

> Please click here to apply <

• Company: The Health and Safety Authority
• Location: Derry

Job Description

The Health and Safety Authority (the Authority) was
established in 1989 under the Safety, Health and
Welfare at Work Act 1989. Additional functions have
been conferred on the Authority since then under
the Safety, Health and Welfare at Work Act 2005, the
Chemicals Acts 2008 and 2010 and other legislation.
In 2014, the Irish National Accreditation Board
(INAB) was included under the Authority’s functions.
The Authority reports to the Minister of State for
Business, Employment and Retail under delegated
authority from the Minister for Enterprise, Trade
and Employment.

What We Do

The Authority has a very broad mandate as
set out below across the areas of occupational
health and safety, chemicals, market surveillance
and accreditation.
■ To regulate the safety, health and welfare of people
at work and those affected by work activities.
■ To promote improvement in the safety, health, and welfare
of people at work and those affected by work activities.
■ To regulate and promote the safe manufacture, use, placing on
the market, trade and transport of chemicals.
■ To act as a surveillance authority in relation to relevant single
European market legislation.
■ To act as the national accreditation body for Ireland.

Open Positions:

Grade III Toxicologist – Information Booklet
Grade III Transport of Dangerous Goods – Information Booklet
Grade III Chemical Exposure Scientist – Information Booklet
Grade III Chemical Market Surveillance – Information Booklet
Grade III Chemical Process Safety –  Information Booklet 

To Apply for the roles please visit: The Health and Safety Authority (HSA) – Conscia Talent

 

The closing date for completed applications is 12:00 8th April 2024.
Applications will not be accepted on the online portal after this deadline. Late applications will be ineligible for consideration. Therefore, it is your responsibility to ensure that you have allowed sufficient time for transmission of your application

• Company: Food Safety Authority of Ireland (FSAI)
• Location: The Exchange, George's Dock, IFSC, Dublin, D01 P2V6
• Salary: €105,500 - 108,138 - 110,776

Job Description

The Chief Specialist Chemical Safety will lead, manage, and develop a team of 4 scientists and together, plan and execute a work programme designed to improve the chemical safety of foods and assists compliance with the technical aspects of chemical safety legislation as it applies to official controls.

 

The application form can be found here

The accompanying Candidate Information Booklet can be found here

The Deadline for applications is Midnight Monday 22nd April 2024.

Please note, candidates must be directed to our Careers Website (Careers | Food Safety Authority of Ireland (fsai.ie)) and upload their Application Form to complete their application. We do not accept Application Forms via email

• Company: UK Health Security Agency
• Location: Chilton, Oxfordshire
• Contract: Permanent, full-time
• Salary: £31,070 - £37,829 per annum

Job Description

This is a unique opportunity to work with public health toxicologists. The post offers training in the delivery of advice on the health effects of chemicals in drinking water, contaminated land and from waste processes. They will work closely with the UKHSA regional chemicals teams in England and Wales, providing advice and support during contamination incidents involving chemicals. The postholder will support various areas of the work of the programme and be required to specialise in a designated area after a period of development in post.  They may also be required to provide toxicological advice in other areas as necessary to support the work of UKHSA.

Further details and information on how to apply can be found at Higher Toxicologist Chilton – Reed.co.uk