AIT webinar series – New computational profiling approaches to identify inhaled sensory irritants

Event Date: January 19th 15:01 - 19th 16:01 2023

Sponsored by the British Toxicology Society (BTS)
Shannon Krieger (Dow Chemical Company)

Sensory irritation, defined as perceived irritation in the nose, throat, and eyes, serves as a protective function following inhalation exposure to irritating substances and is frequently used as a critical effect in setting occupational exposure limits. Transient receptor potential (TRP) channels are important biological targets for sensory irritation, with TRPV1 and TRPA1 being two of the most predominant TRP channels in the respiratory tract.  We have developed a machine learning model for TRPV1 and a computational profiler for TRPA1 to predict compounds that may interact with these two important targets. Our goal is to predict the sensory irritation potential of unknown compounds to address potential human exposure using NAMs and to minimize the need for in vivo testing.   

Please register your interest in attending each session by emailing the webinar organiser Kay Rush at Links to join each session will be sent to people that are registered.