This module is focussed on understanding mechanisms of toxicity at the molecular level. In a number of lectures and case-studies, molecular mechanisms underlying (organ-selective) toxicity and carcinogenicity will be discussed. Special emphasis will be on the role of drug metabolism and bio(in)activation in toxicology. Topics include: multiplicity and properties of drug-metabolising enzymes (cytochrome P450, glutathione S-transferases and others); experimental approaches to characterize enzymes involved in drug metabolism; clinical and toxicological consequences of genetic polymorphisms of drug metabolising enzymes; chemical and biological properties of reactive intermediates responsible for toxicity; mechanisms underlying idiosyncratic drug reactions; novel computational approaches to predict drug metabolism and toxicity; and, mechanisms determining organ-selective toxicity. Participants should have a sound knowledge of basic organic chemistry to be able to fully profit from this course.
Course Type: Commercial Courses
Learning Type: In Person
Start Months: The next course is scheduled for 2024, but the exact dates have not been specified yet.
Course Duration: Full Time
Full Time Hours: 1 week
Qualifications Required: No formal qualification
Cost: €330 internal PhD student, €550 external PhD student, €1650 other
Contact details of organiser: Postgraduate Education in Toxicology (PET)