Here are current Toxicology job advertisements. Click on the plus icon to see further details and to access any associated files for download. Responses should be made to the appropriate contact point detailed in the advert.

Programme Manager

Company: NC3Rs
Job Title: Programme Manager – 3Rs in vaccine batch release and quality control testing
Salary: £39,216 – £45,843 plus London allowances
Location: London
Contract type: Three years fixed term (full-time) – possibility to extend if budget is available


 Science-led and evidence-based, the NC3Rs is the UK’s national organisation for the 3Rs, established in 2004 to accelerate the development and uptake of new models and tools that replace, reduce or refine the use of animals in research and testing. The NC3Rs is primarily funded by Government and has an annual budget of approximately £10 million. Its activities are divided between its role as the UK’s major 3Rs research funder and programmes led by its own team of scientists. Further information can be found at

Role of the Programme Manager

The NC3Rs has a strong track record in successfully embedding the 3Rs in the policy, practice and regulations of organisations across the bioscience sector, nationally and internationally. We achieve this through our role as an honest broker, providing an impartial environment for data and knowledge to be shared across companies and sectors as a means for identifying new 3Rs opportunities within current company practice and regulatory requirements.

We are collaborating with the World Health Organization (WHO) to extend these activities to the batch release and quality control testing of vaccines and other biologicals. It has been estimated that more than 10 million animals a year are used worldwide in vaccine development and manufacture and that 80% of these animals are used for routine quality control and batch release tests of licensed products. WHO guidelines and recommendations for the development and manufacture of biologicals carry significant influence and are adopted by a majority of global regulatory authorities, but it is not clear how much animal testing is recommended within them. Opportunities to embed the latest technologies into the development pipeline of biologics are being missed and animal tests that are expensive and often poorly predictive continue to be used.

This three-year project, jointly funded by the NC3Rs and the Bill and Melinda Gates Foundation, will:

  • Review existing WHO biologics and vaccines guidelines for requirements of animal testing in product control and release testing;
  • Evaluate the barriers to acceptance and adoption of 3Rs practices among biologics manufacturers, national control laboratories and WHO member states;
  • Develop a set of recommendations for the inclusion of 3Rs methods within existing WHO guidelines for human vaccines and biologics.

Widescale implementation of the recommendations will enable vaccines manufacturers and regulators to apply the latest non-animal testing approaches and strategies to support faster access to cheaper vaccines by the global communities who need them most urgently.

The main responsibilities of the Programme Manager include:

  • Developing surveys and analysing survey data to gather an evidence-base to support the development of recommendations for the inclusion of 3Rs methods in WHO guidelines.
  • Convening an expert working group and supporting the work on reviewing WHO guidelines for opportunities to include the 3Rs.
  • Organise working group meetings including preparing the agenda, meeting minutes and overseeing delivery of action points.
  • Preparing annual project update reports for the working group and project funders.
  • Organising international workshops and symposia to engage the global biologics community in the project and to understand regional barriers and opportunities for the adoption of 3Rs approaches.
  • Prepare workshop reports/publications and other dedicated communication materials to promote the outputs from the project.
  • Building strong relationships both internally and externally.
  • Delivering NC3Rs’ programme to support the adoption of the 3Rs in the biologics field.
Person specification
Education and qualifications §  PhD in a biological science

Knowledge and experience


§  Vaccines/biologics research and development (preferably post-licensure) and significant post-doctoral experience, or industry equivalent.

§  Knowledge/experience of biologics regulatory landscape (desirable but not essential).

§  Knowledge/experience of WHO biologics guidelines (desirable but not essential).

§  Proven experience in organising and running large workshops and symposia.

§  Proven experience in reviewing scientific publications and manuscripts.

§  Experience of prioritising and planning workload to meet multiple and/or tight deadlines without compromising quality or working relationships.

Personal skills/ qualities

§  Excellent understanding of the use of animals in research and a demonstrable commitment to the 3Rs.

§  Ability to represent the NC3Rs at national and international meetings.

§  Strategic and pragmatic thinker; with the ability to identify, analyse and propose solutions to varied and complex problems.

§  Excellent interpersonal skills; works well as part of a dynamic team, as well as the ability to effectively network with stakeholders from a diverse range of roles and levels of seniority.

§  Excellent communication skills, both written and verbal.

Additional information

­The post is within the NC3Rs Science and Technology Group and the Programme Manager will report to Dr Anthony Holmes, Director of Science and Technology at the NC3Rs. The post will be based primarily in London but will be required to attend meetings in other UK and/or overseas locations.

The post holder will need to work early and/or late when required – especially around key meetings and events.

There will be no formal staff line management responsibilities.

The successful candidate will be subject to security checks.

The closing date for applications is Friday 14 August.

Please visit the MRC vacancies portal for further information, including how to apply.

Please ensure you include a copy of your CV and a covering letter explaining how you meet the criteria listed in the person specification.

Interview date is Wednesday 2 September.


Company: Health & Safety Executive
Job Title: Toxicologist
Salary: £25,674 (rising to £30,821 after successful completion of training)
Location: Bootle or York

This is science with a unique remit. At the Chemicals Regulation Division of the Health & Safety Executive, everything we do is for one vital purpose: to protect the environment and human health from potentially harmful substances, whilst enabling the use of chemicals in Great Britain. Ours is a passionate commitment.

As a Regulatory Toxicologist, you will provide technical input to regulatory programs, with a particular focus on delivering HSE objectives as we exit from the European Union. This includes the assessment of the human health hazards and risks of a wide range of chemicals, pesticides and biocides and their formulations. You will share your results internally and externally, to expert committees, other government departments and relevant stakeholders.

This is an opportunity to build a worthwhile career in regulatory science. Alongside a structured training programme lasting at least 18 months, you will gain valuable experience in national and international chemical legislation, communicating with stakeholders, strategic planning, scientific writing and regulatory decision-making.

We’re looking for people with a minimum 2.2 degree in a science-based discipline. You’ll possess drive, determination and good planning skills, along with a collaborative approach and strong communication skills. Highly analytical, you’ll also be proficient in Microsoft Office.

To find out more about careers within HSE’s Chemical Regulations Division, join our webinar on Tuesday 4th August at 1pm. You will have the opportunity to hear from some of our regulatory scientists about their experiences and the impact of their work. Secure your place at the webinar by registering for the event on our website Click Here

To find out more and apply, please visit our website

Closing Date – Sunday 9th August 2020

Senior Manager, Toxicology Scientist

Company: GW Pharmaceuticals
Job Title: Senior Manager, Toxicology Scientist
Location: Cambridge, Office Based and Home based

About GW:
GW Pharmaceuticals is a cutting-edge UK-based biopharmaceutical company that over the last 20 years has established a world-leading position in cannabinoid science and the development of regulatory approved medicines derived from cannabis. Our mission is to transform the lives of seriously ill patients and their families. In October 2018 our achievements were recognized by TIME magazine which named GW as one of the ‘Top 50 Genius companies of 2018 that are inventing the future’.
Having developed the world’s first prescription medicine derived from the cannabis plant, Sativex®, which treats spasticity due to multiple sclerosis GW has now developed an oral formulation of purified cannabidiol (CBD), (approved as Epidiolex® in the U.S) for seizures associated with Lennox-Gastaut syndrome or Dravet Syndrome, two rare and severe early-onset, drug-resistant epilepsy syndromes. This is in addition to our deep pipeline of clinical stage cannabinoid product candidates under development for both orphan and non-orphan indications with a particular focus on neurological conditions.
We are continuing to build out our teams and are looking for talented individuals dedicated to making a difference in the lives of our patients, and to exemplifying our company values.
Please go to for additional information.
About the Role:
The Senior Manager, Toxicology directs, leads and manages a proportion of the Preclinical Toxicology team and manages/oversees non-clinical GW Toxicology projects from conceptualisation and study design through to study report finalisation and subsequent scientific publications, and inclusion in regulatory documentation.
The Senior Manager, Toxicology reports to and is line managed by the Associate Director, Toxicology.

• Direct, lead and manage a proportion of the Preclinical Toxicology team
• Manage non-clinical GW toxicology studies as determined by the needs of the organisation
• Provide strategic input into functional goals and activities
• Propose, manage and revise (as appropriate) timelines for toxicology studies and programmes
• Ensure preclinical toxicology studies are run in accordance with the relevant regulatory guidelines as required
• Maintain good working relationships with relevant key leaders and vendors
• Supported by Preclinical Operations and in collaboration with other Preclinical Managers, is accountable for timely and effective management of the Preclinical Toxicology budget
• Define and manage all Preclinical Toxicology study/programme resource needs and establishes relevant contingency plans
• Oversee the material requirement for the GW Toxicology studies to ensure that materials are always available
• Manage and provide technical input into scientific reports from CROs
• Contribute to regulatory, pharmacovigilance and medical affairs documents as required to meet corporate needs
• Contribute to Function and/or Programme Teams as determined within the governance matrix structure
• With support from the Associate Director, Toxicology and Preclinical Operations team, is accountable for devising, agreeing, implementing and monitoring toxicology team departmental processes and governance structures
• Develop the Preclinical Toxicology team via training and/or opportunities. Leads (or delegates) appropriate training to educate relevant GW employees with regards to Toxicology as required

• A degree (BSc) and either higher degree (PhD or MSc) in Toxicology or another appropriate scientific discipline with relevant experience
• ERT/UKRT certification desirable
• Strong industry experience in a similar role
• Extensive experience in Toxicology department of a pharmaceutical company or equivalent
• Strong and proven experience in managing a high performing team
• Knowledge of the pharmaceutical drug development process
• Proven ability of high functioning in a matrix organisation
• Relevant experience in scientific writing for externalisation and regulatory purposes
• Organisational skills, proven time management ability and the ability to effectively prioritise
• Ability to use initiative and problem solve
• Ability to lead, direct, manage and develop others
• Good communication skills
• Written and verbal presentation skills
• Excellent attention to detail
• Ability to work in a team and as an individual
• Working knowledge of Excel, Word, PowerPoint, Endnote, search engines and databases used for literature searches, and relevant scientific software
• Demonstrates a pragmatic approach to problem solving
• Self-motivated approach, with a willingness to assist colleagues to achieve goals

To Apply please submit your application on our website via the below link—Cambridge/Senior-Manager–Toxicology-Scientist_R0001590

Senior Non-Clinical Toxicologist

Company: UCB
Job Title: Senior Non-Clinical Toxicologist
Location: Braine-l’Alleud Braine-l’Alleud, Wallonia, Belgium

UCB Company Location Braine-l’Alleud Braine-l’Alleud, Wallonia, Belgium

UCB, Brussels, Belgium ( is a global biopharmaceutical company focused on the Discovery and development of innovative medicines and solutions to transform the lives of people living with severe diseases of the immune system or of the central nervous system. With more than 8 500 people in about 40 countries, the company generated revenue of € 4.5 billion in 2017. UCB is listed on Euronext Brussels (symbol: UCB)

Senior Non-Clinical Toxicologist with Drug Development Experience and Expertise in Neurosciences

We are currently seeking an experienced Toxicologist with expertise in Neuroscience therapeutic area (neurodegeneration, neuroinflammation, epilepsy). You will be responsible for the non-clinical development of small molecule, mAB, and new modalities drug candidates. You will provide non-clinical support to global project teams from early research through to FIM, POC and beyond. You will work in a collaborative environment and as a member of interdisciplinary project teams; you will represent the Development Science Department. You will demonstrate high skills in monitoring GLP studies with CRO’s, provide toxicology interpretation and issue resolution; and participate in various toxicology and R&D initiatives or other active cross-functional collaborations. You will also prepare and review regulatory documentation and represent UCB in meetings with regulatory authorities. Ideally, the position will be in Brussels area (Belgium).

The profile:

The ideal candidate should have a dynamic personality, have a degree related to toxicology (e.g. biomedical science, pharmacology, DVM, or Ph.D.) with at least 10 years of experience in non-clinical development in a multidisciplinary environment (DMPK, clinical pharmacology) with primarily NCEs, however, experience with NBEs is also an asset. He/she would have strong knowledge in Neuroscience therapeutic area (neurodegeneration, neuroinflammation, epilepsy), have experience of regulatory toxicology and GLP compliance in the pharmaceutical industry.

An experience of new therapeutic modalities such as gene therapy, PROTACs or cell therapy is a strong asset. Due to the nature of the position, you need to consider the following desirable assets:

  • Excellent interpersonal skills to facilitate interactions; excellent oral and written English communication skills. Demonstrated technical writing skills.
  • Demonstrated problem-solving, strong decision-making, complex problem-solving.
  • Demonstrated critical data analysis and interpretation.
  • Demonstrated ability to work independently and as a strong collaborative member of diverse teams.
  • Open, confident, and persuasive behavior, succeeding through influence, experience in balancing big picture thinking with detailed analysis, ability to be flexible and to adapt to a changing environment.

To Apply:

If you are interested, please go to'alleud-Senior-Non-Clinical-Toxicologist-Wall/515511301/

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