VACANCIES

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Here are current Toxicology job advertisements. Click on the plus icon to see further details and to access any associated files for download. Responses should be made to the appropriate contact point detailed in the advert.

Senior Toxicological Advisor

Company: Food Standards Agency
The role: Senior Toxicological Advisor
Location: Cardiff, Birmingham, London or York; Multi Location or Home based. Successful candidates will be expected to travel to London for the initial training period and up to once a week thereafter for team and Scientific Advisory Committee meetings. There may be occasional overnight stays required
Deadline: 10th November 2019
Salary: £33,625 – £45,107

Summary

The FSA is a non-ministerial department of over 1300 people, with a big vision – to drive change in the food system so that it delivers “food we can trust” – as the country prepares to leave the EU, the scale of this challenge cannot be underestimated. More than 90% of food and feed law in the UK currently comes from Europe and our primary goal is to continue to protect public health and UK consumers’ wider interest in food.

An exciting opportunity has arisen as part of the expansion of the Risk Assessment Unit

Job description

If successful, the applicant will manage the work of the additives and supplements team, line managing two HSOs and their work and being involved in a varied range of risk assessment activities ranging from enquiries and incidents to preparing detailed papers for discussion by our Expert Scientific Advisory Committees.
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Please read the attached Candidate Pack to discover further details about the role, our organisation, who we are looking for and the criteria we will assess against during the selection process. We look forward to receiving your application and wish you every success.

Responsibilities

As someone with pride and passion for public service, you’ll recognise the wider Civil Service priorities and always work in the national interest. You’ll seek out opportunities to create effective change and suggest innovative ideas for improvement. You’ll use evidence and knowledge to support accurate, expert decisions and advice. You’ll value difference, diversity and inclusion, ensuring fairness and opportunity for all.

Qualifications

Degree in appropriate life science

Project Toxicologist in Oncology

Company: AstraZeneca
The role: Project Toxicologist in Oncology
Location: Cambridge
Deadline: 23rd November 2019
Salary: Competitive

AstraZeneca is a major international healthcare business engaged in the research, development, manufacture and marketing of prescription pharmaceutical and the supply of healthcare services. But we’re more than one of the world’s leading pharmaceutical companies. At AstraZeneca we’re proud to have a unique workplace culture that inspires innovation and collaboration. Here, employees are empowered to express diverse perspectives and are made to feel valued, energized and rewarded for their ideas and creativity. We are investing in a state-of-the-art research center in Cambridge where we will bring together some of the finest talent in business and academia.

Oncology Safety, a global department that is part of our Clinical Pharmacology and Safety Sciences (CPSS) function applies innovative science to drive the design, selection and development of safer medicines. The Oncology Safety group work collaboratively delivering safety science from early discovery through clinical development.  An exciting opportunity now exists within our Oncology Safety Department for a talented Project Toxicologist to join us to support the development of innovative Oncology drugs and restore patients’ lives.

As a Project Toxicologist you’ll be part of a dynamic, collaborative team working in a vibrant environment, where you’ll help us make a difference to patients world-wide.

In CPSS, we place a strong emphasis on individual talent development. You will be able to develop your scientific leadership and skills by working together with leaders in bio-science, chemistry, DMPK, modelling, investigative toxicology, oncology drug discovery, quantitative safety science and regulatory toxicology.

Main Duties and Responsibilities

As a Project Toxicologist working across discovery and development, you will apply innovative investigational toxicology science to enable the discovery and development of safer medicines for patients. Once a compound is selected for development you will design and interpret toxicology research programmes and ensure delivery of high quality regulatory toxicological documentation to enable clinical studies and marketing authorization of drug candidates. Within Oncology Safety we are leading a patient-centric approach and you will focus on working with cross discipline experts to combine clinical and non-clinical science to determine the optimal development path of our Oncology portfolio.

To succeed as a Project Toxicologist you’ll need a collaborative, consultative approach to projects and the ability to apply your skills to:

  • Explore drug project safety risks and develop risk mitigation strategies, by combining data from traditional toxicological methods with data from more novel approaches and computational tools to build mechanistic understanding of drug leads and candidates
  • Work with experts from diverse disciplines including, in vitro toxicology, computational toxicology, secondary pharmacology, safety pharmacology, pathology and advanced imaging data science
  • Understand the practices, principles and concepts associated with planning and delivering fit for purpose non-clinical toxicology study programs
  • Deliver non-clinical safety packages to support all phases from candidate drug selection to early clinical development.  Experience of marketing applications would be an advantage
  • Deliver summaries and high-level documents based on scientific interpretation of data regarding toxicology and risk assessment to internal decision bodies and external health authorities
  • Provide specialist non-clinical expertise for evaluation of in-licensing and out-licencing opportunities
  • Provide strategic input to the long-term development of the organization
  • Embrace change and thrive in a dynamic working environment that is evolving to meet the needs of the business and the patient.

Essential Requirements

As a Project Toxicologist your qualifications, skills and experience will ideally include:

  • DVM, PhD or MSc in Pharmacology, Toxicology or a related Life Science discipline
  • Safety assessment experience from preclinical research and development work within the pharmaceutical industry
  • Good command of pharmacological and / or toxicological principles and methods and the ability to familiarize with new therapeutic approaches
  • Familiarity with, and the application of, appropriate regulatory principles and guidelines and the enthusiasm to work within and contribute to the discipline of Toxicology in a drug development setting

Experience of working with small molecule, biologics, new modalities and/or combination oncology therapies is particularly welcomed.

At AstraZeneca we aim to be a great place to work, and as part of this commitment support flexible working arrangements where possible.

Click HERE to Apply

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